Autoimmune thyroiditis: A model uniquely suited to probe regulatory T cell function
نویسندگان
چکیده
منابع مشابه
Concurrent induction of antitumor immunity and autoimmune thyroiditis in CD4+ CD25+ regulatory T cell-depleted mice.
When CD4+ CD25+ regulatory T cells are depleted or inactivated for the purpose of enhancing antitumor immunity, the risk of autoimmune disease may be significantly elevated because these regulatory T cells control both antitumor immunity and autoimmunity. To evaluate the relative benefit and risk of modulating CD4+ CD25+ regulatory T cells, we established a new test system to measure simultaneo...
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Selenium (Se) is required for thyroid hormone synthesis and metabolism. Se treatment reduces serum thyroidspecific antibody titers in patients with autoimmune thyroiditis (AIT), but the exact mechanism is not clear. We investigated the effects of Se treatment on CD4+CD25+Foxp3+ regulatory T cells (Treg) in a iodine-induced autoimmune thyroiditis model. NOD.H-2h4 mice were randomly divided into ...
متن کاملRegulatory T Cell Therapy for Autoimmune Disease
It has now been well documented in a variety of models that T regulatory T cells (Treg cells) play a pivotal role in the maintenance of self-tolerance, T cell homeostasis, tumor, allergy, autoimmunity, allograft transplantation and control of microbial infection. Recently, Treg cell are isolated and can be expanded in vitro and in vivo, and their role is the subject of intensive investigation, ...
متن کاملA rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy.
Regulatory T cells (CD4(+)CD25(hi)CD127(lo)FOXP3(+) T cells [Tregs]) are a population of lymphocytes involved in the maintenance of self-tolerance. Abnormalities in function or number of Tregs are a feature of autoimmune diseases in humans. The ability to expand functional Tregs ex vivo makes them ideal candidates for autologous cell therapy to treat human autoimmune diseases and to induce tole...
متن کاملRegulatory T Cells and Vitamin D Status in Children with Chronic Autoimmune Thyroiditis
OBJECTIVE It is suggested that vitamin D is one of the factors that can regulate the function of Treg cells. In this study, the relationships between Treg cells and vitamin D levels was investigated in pediatric chronic autoimmune thyroiditis (CAT) patients. METHODS Thirty-two children with CAT and 24 healthy subjects were studied. FOXP3 expressing CD4+CD25+high Foxp3+T cells were identified ...
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ژورنال
عنوان ژورنال: Journal of Autoimmunity
سال: 2009
ISSN: 0896-8411
DOI: 10.1016/j.jaut.2009.09.004